Journal: Journal of Personalized Medicine

Article Title: Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms

doi: 10.3390/jpm13121689

Figure Lengend Snippet: Preclinical and clinical studies investigating shared biological mechanisms in patients with HIV and depression/anxiety symptoms/syndromes.

Article Snippet: Taylor et al. 2023 USA [ ] , Cross-sectional study with151 participants (84 HIV+, 67 HIV−), subgrouped as follows: (a) HIV−/MDD− (3F, 20 M; 45.7 ± 13.5 years); (b) HIV−/MDD+ (14 F, 30 M; 45.0 ± 12.6 years); (c) HIV+/MDD− (2F, 18 M; 44.5 ± 14.3 years); and (d) HIV+/MDD+ (8F, 58 M; 46.1 ± 11.3 years). , Neuromedical and laboratory assessment , CIDI; BDI-II , Shallow-shotgun metagenomic sequencing of blood microbiome bacterial DNA. , The microbial composition did not differ between the PWH and the PWoH or between the participants with MDD and those without, though the patients with HIV infection and lifetime MDD showed a set of plasma microbiome community of the inflammatory classes, such as Flavobacteria and Nitrospira. The circulating plasma microbiome may increase the risk of MDD related to dysbiosis-induced inflammation in PWH..

Techniques: Injection, Modification, Gene Expression, Expressing, Western Blot, Transgenic Assay, Control, Saline, Cell Counting, Virus, Biomarker Discovery, Battery, Clinical Proteomics, Concentration Assay, Quantitative RT-PCR, Sampling, Activation Assay, Quantitation Assay, Derivative Assay, Infection, Medications, Immunohistochemical staining, Enzyme-linked Immunosorbent Assay, Combined Bisulfite Restriction Analysis Assay, Sequencing